Sebastian Seung seminar, Foege S060, 2pm October 14.

Space-time wiring specificity supports direction selectivity in the retina

The perception of motion is a basic visual ability, and already begins in the retina. Some retinal outputs (ganglion cells) respond selectively to stimuli moving in particular directions, but retinal inputs (photoreceptors) are not direction selective (DS). How does DS emerge from the microcircuitry connecting inputs to outputs?  In search of clues, we reconstructed starburst amacrine cells (SACs) and bipolar cells (BCs) in serial electron microscopic images with help from EyeWire, an online community of volunteer neuroanatomists. Based on quantitative contact analyses, we found evidence that the two ends of each SAC dendrite are wired to BC types with different time lags in visual response.  A mathematical model shows how such “space-time wiring specificity” could endow SACs with receptive fields that are oriented in space-time, and hence with visual responses selective to direction of motion.

Computational Neuroscience Connection 2014 (registration free but required)
CSNE and Waterfront Activities Center
September 25 and 26

Sloan-Swartz meeting on Computational Neuroscience to be held in Seattle, June 25-28 2014.

Computational Neuroscience talks around campus

Fall 2013 Weekly Thursday Research Club

Research Club, meeting each week at 3pm in HSB G417 (unless otherwise noted), will offer a mix of excellent visiting speakers and presentations hosted by rotating labs strongly directed toward discussion of open problems. Formal sessions will be no longer than one hour, followed by refreshments and discussion.

Computational Neuroscience Google Calendar

Journal Clubs